i just sold my 3 UAD-1 cards on ebay (keeping my UAD-2 Quad of course). They ran no problems on Win 7 64 bit with Cubase 64 bit and j-bridge and same RAM spec as you with 8GBs. Highly recommend j-bridge - it's cheap, it works and it's easy to install. I'm still running on an old Intel Quad core Q9300 which is maybe 4 or 5 years old and it's solid as a rock. I don't know Studio One but with the objective of getting maximum benefit with your RAM usage I would advise installing the 64 bit version. Then you can use j-bridge to bridge any 32 bit plugins or virtual instruments into the 64 bit address space.